Why should we use 46.4 as z value in dry sterilzation as recommended z value of dry amps r 29?give me xvt rationale for this?

GOOD VALIDATION PRACTICE (cGVP) PROCESS VALIDATION
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Dry sterilization in hot air oven

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Z-value which is the temperature increment to reduce D-value by a factor of 10 (Z = 46.4°C for E.coli endotoxin). As mostly E.Coli endotoxins are used to determine 3-log or 6-log reduction, the reference value of 46.4 is used.

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Tnk for u rply can u breifly xplan about it sir