Dear Experts,
We are getting so much problem during the micronization / Jet Milling. Usually we are fixing the Jet mill parameters like Feed RPM, Feed Pressure and Base pressure by considering 3 batches trials. But these parameters are not giving required particle size material even though we consider these three batches micronisation parameters. Due to this we are spending lot of time for performing the particle size analysis by Malvern Instrument.
Exactly what parameters we needs to consider to get the required particle size? Is there any study shall be performed? Can any one guide us in this issue to overcome? We are looking our experts input in this matter.
Thanks in advance.
Pulla Reddy Karnati.
[quote=Pulla Reddy]Dear Experts,
We are getting so much problem during the micronization / Jet Milling. Usually we are fixing the Jet mill parameters like Feed RPM, Feed Pressure and Base pressure by considering 3 batches trials. But these parameters are not giving required particle size material even though we consider these three batches micronisation parameters. Due to this we are spending lot of time for performing the particle size analysis by Malvern Instrument.
Exactly what parameters we needs to consider to get the required particle size? Is there any study shall be performed? Can any one guide us in this issue to overcome? We are looking our experts input in this matter.
Thanks in advance.
Pulla Reddy Karnati.[/quote]
Dear Mr. Pulla Reddy,
Good morning…
Please let us know the parameters you operated on your machines and what was the particle size you achieved.
Please write all the information in detail… so that it would be easier to discuss…
Regards,
Bujji Reddy Kanchi.
9676749937
My advice to both of you guys is that take back to the lab and let R&D decide this. You can only rectify this problem if you are thoroughly knowledgeable in Pharmaceutics. Better look at the machinery first and then suitability of raw materials and process parameters etc.
Do not mess it up. It is not as easy as one thinks.
[quote=DURGA PRASAD]My advice to both of you guys is that take back to the lab and let R&D decide this. You can only rectify this problem if you are thoroughly knowledgeable in Pharmaceutics. Better look at the machinery first and then suitability of raw materials and process parameters etc.
Do not mess it up. It is not as easy as one thinks.[/quote]
Of-course, that’s a good practice to contact R&D,
However, I would like to involve in this. since I have good experience in those cases.
Usually The parameters are to get the particle size below 10µm
Inlet Air pressure : Not less than 7 Kg
This 7 kg air will be splitted into two ways 1) feeder 2) Microniser
Feeder air pressure should be less than Jet mill(microniser) air pressure.
One more parameter is screw feeder , It should be about 10 RPM.
Some times Bulk density of the material depends.
We should consider the bulk density of the material before micronisation.
The bulk density should be above 0.7 g/mL.[ if not, proceed compacting followed by milling to achieve proper bulk density].
Pulverisation gives about 200µm size almost.
Now set the RPM of microniser for the required .
This is for your information only.
Regards,
Bujji Reddy Kanchi.