Could you please help me with one problem:
How can I calculate NOEL and MACO for non human products. To be clear: in all documents about cleaning validation I found this formula for NOEL:
NOEL=LD50 x 70kg/2 000, where 70kg is average weight of an adult. But which weight I have to insert in NOEL formula, when my products are for animals (pigs, cows, horses, dogs…).
And what I have to do when one product is used in healing for many types of animals with difrent average weight. Do I have to use a smallest average weight (average weight for smallest animal) and in MACO formula use therapeutic daily dose for that animal.
Thank you in advance for helping me.