After Lubricant mixing, then I fill capsule. When I test dissolution of capsule, it does not dissolve. It forms a clot. When I check the history of processing, I found that we mix the mixture with lubricant (magnesium stearate, aerosil) too long (15 minutes). How can I solve this problem ? Thanks all.
Reduce the mixing time with magnesium stearate. Magnesium stearate forms a film on the particles at longer mixing. Other question, why magnesium stearate in a capsule formulation? In a tablet granulate magnesium stearate prevents sticking…