Dissolution RPM speed

GOOD VALIDATION PRACTICE (cGVP) LABORATORY, METHOD AND ANALYTICAL VALIDATION
1

Dear All,

Please advice,

Can we use paddle speed (apparatus 2) 150rpm in dissolution testing of modified release dosage forms.

Regards

Saleem Jawed

2

Dear saleem
Generally 150 RPM for paddle not acceptable due to turbulance effect of apparatus in media.
you can use Paddle at 150RPM ,if you are justified.