Can Gelatin Solution be filter sterilized using a 0.22 micron filter?

GOOD MANUFACTURING PRACTICE (cGMP)
1

I would like to know if anyone has ever filter sterilized gelatin solution through 0.22micron filter. If yes, please let me know the critical process parameters and also the type of filter membrane used.

Can Gelatin Solution be filter sterilized using a 0.22 micron filter?

2

It depends on the concentration of the gelatin solution. 1% is probably yes, while 50% is definitely NO! Why don’t you heat sterilize it in an autoclave?