[quote=durga prasad]heparin is a heterogenous group of straight-chain anionic mucopolysaccharides, called glycosaminoglycans, having anticoagulant properties.
Heparin is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups. In heparin sodium, the acidic protons of the sulfate units are partially replaced by sodium ions.
The ph of heparin sodium injection is 5.0-7.5 which can be adjusted with hydrochloric acid or sodium hydroxide.
Type -1 glass is a neutral galss or boroscillicate glass having high hydrolytic ressitance and can withstand any ph and offers product stability.
Type -iii glass is soft glass or sodalime glass.
"we should not fill any liquid products into that.used only for dry products that are immediately reconstitued and used also for oily preperations.
If you make heparin in this the stability changes and causes serious adverse reactions to patients like profuse bleeding.[/quote]
thanks durga prasad for your reply
i was just thinking that soda lime treated vials are being leached when they come in contact with aqueous phase of injection & this can effect the stability of the product.
And when i explained this to my superiors they asked me weather iam having any data regarding this explanation.