In-process Sampling

Dear All,
Is there Some one to solve my problem of process validation sampling :
01-During Granulation How much samples should we take ?
02-What technique should we use to withdraw samples ?
03-How can we take Layerwise samples in suspensions ?
04-upto how many days should we do holding study of in-process material ?
05-In case of granules sampling with sampling rod is difficult ,is there another option for it ?
06-In routine manufacturing should we follow multi location sampling with samping rod or one pool sample is sufficient ?

Hope fully some will resolve mine quiries sonnly .

Panakj Kr.Sharma:o