HPLC prep method validation

Hello all,

How can I validate a HPLC prep method?

In short, the process is like that : DNA oligos are synthesised, then purified on a HPLC prep, and finally analyzed by the QC.

Our QC, use an analytical HPLC. And the methods are all validated according to ICH guidelines (repeatability, specificity, linearity and accuracy// LOD LOQ are not studied because we don’t quantify on HPLC).
I don’t think that all of these parameters need to be verified on a HPLC prep method, isn’t it?

HPLC prep method validation has to be lighter then analytical method validation.

Sorry for the mistakes,
Best regards

IMO, accuracy could be used to determine preparation procedures in your method.