Ep 2.2.32 loss on drying

Good day!
Help solve the problem!
Article 2,2,32 indicated a deviation from the mean daily temperature setting ± 2 degrees Celsius.
But when dried in a vacuum, we take away from the coolant system. And to achieve this precision temperature, with an almost complete lack of air - it is not possible. Or am I wrong?
Someone had met with a similar problem?