Desicant De Humidifyer

Hi all. I am required to Qualify new HVAC installations that have enviromental criteria of <27% RH. This will be attained using a chemical desicant wheel and chilled water cooling coils. I am well versed in the whole HVAC qualification scenario except for the desicant wheel which I have never had the pleasure of qualifying with the whole package.
My questions are; what do I have to look out for when attempting this project that common sense will not bring to the forefront and what approach should I take to cover the possible nasty of contamination?