Cleaning agent removal

how to calculate MACO for cleaning agent?

Can be calculated on the basis of Toxicological Data of detergent:
NOEL= LD50 (of Detergent) x 70kg/2000.
(MACOD)= NOEL (of Detergent) x MBS / SF x TDD(Next)
TDDnext: Largest normal daily dose for the next product
MBS: Minimum batch size for the next product